Arms dealer Yolaf Peterson aims to make a sale to guerilla Mongo, but the money is locked in a bank safe, the combination known only to Professor Xantos, a prisoner of the Americans. Yolaf agrees to free Xantos, accompanied by reluctant guerilla Basco, but a former business partner of Yolaf's- John 'The Wooden Hand', has other ideas.
When the members of a caravan of pioneers find a daisy growing in the middle of the desert they decide to stop there and to build their town on this very spot. Houses soon spring up like mushrooms, immediately followed by a bank, a saloon, a prison, etc. Daisy Town is born. Unfortunately a city does not go without its bad boys and the peaceful place is soon turned into a lawless place. To restore law and order, a lawman is needed. Lucky Luke, the cowboy who shoots faster than his shadow, will be this man: all the villains had better watch out!
The story opens in a Western saloon, where a young musician with a banjo begins to tell a tale of Lucky Luke and his sworn enemies the Dalton brothers: Joe, William, Jack and Averell. Luke has, once again, as he has done many times before, thrown the four outlaws into jail. The prison is also the abode of a guard dog named Rin Tin Can (Rantanplan in the original French language version).
While passing through the town of Bannock, a bunch of drunken cattlemen go overboard with their celebrating and accidentally kill an old man with a stray shot. They return home to Sabbath unaware of his death. Bannock lawman Jered Maddox later arrives there to arrest everyone involved on a charge of murder. Sabbath is run by land baron Vince Bronson, a benevolent despot, who, upon hearing of the death, offers restitution for the incident.
When vigilante land baron David Braxton hangs one of the best friends of cattle rustler Tom Logan, Logan's gang decides to get even by purchasing a small farm next to Braxton's ranch. From there the rustlers begin stealing horses, using the farm as a front for their operation. Determined to stop the thefts at any cost, Braxton retains the services of eccentric sharpshooter Robert E. Lee Clayton, who begins ruthlessly taking down Logan's gang.
The Apache Indians have reluctantly agreed to settle on a US Government approved reservation. Not all the Apaches are able to adapt to the life of corn farmers. One in particular, Geronimo, is restless. Pushed over the edge by broken promises and necessary actions by the government, Geronimo and thirty or so other warriors form an attack team which humiliates the government by evading capture, while reclaiming what is rightfully theirs.
Henry Moon is captured for a capital offense by a posse when his horse quits while trying to escape to Mexico. He finds that there is a post-Civil War law in the small town that any single or widowed woman can save him from the gallows by marrying him.
At the beginning of the 20th century, a newspaper organizes an endurance horse race : 700 miles to run in a few days. 9 adventurers are competing, among them a woman, Miss Jones, a Mexican, an Englishman, a young cow-boy, an old one and two friends, Sam Clayton and Luke Matthews. All those individualists will learn to respect each other.
Hannie enlists the aid of bounty hunter Tom Price to teach her how to be a gunfighter so she can hunt down the 3 men who killed her husband and raped her.
J.D. Cahill is the toughest U.S. Marshal they've got, just the sound of his name makes bad guys stop in their tracks, so when his two young boy's want to get his attention they decide to rob a bank. They end up getting more than they bargained for.
Arizona Territorial Prison inmate Paris Pitman, Jr. is a schemer, a charmer, and quite popular among his fellow convicts — especially with $500,000 in stolen loot hidden away and a plan to escape and recover it. New warden Woodward Lopeman has other ideas about Pitman. Each man will have the tables turned on him.
Jim Craig has lived his first 18 years in the mountains of Australia on his father's farm. The death of his father forces him to go to the lowlands to earn enough money to get the farm back on its feet.
Double-crossed and left without water in the desert, Cable Hogue is saved when he finds a spring. It is in just the right spot for a much needed rest stop on the local stagecoach line, and Hogue uses this to his advantage. He builds a house and makes money off the stagecoach passengers. Hildy, a prostitute from the nearest town, moves in with him. Hogue has everything going his way until the advent of the automobile ends the era of the stagecoach.