Chief Sitting Bull of the Sioux tribe is forced by the Indian-hating General Custer to react with violence, resulting in the famous Last Stand at Little Bighorn. Parrish, a friend to the Sioux, tries to prevent the bloodshed, but is court- martialed for "collaborating" with the enemy. Sitting Bull, however, manages to intercede with President Grant on Parrish's behalf.
At the end of the Civil War, Frank and Jesse James and other former guerillas who rode with Quantrill and Bill Anderson take the oath of allegiance to the Union. Feeling oppressed by Chicago railroad investors, the James and Younger brothers, Bob and Charlie Ford, Clell Miller and Arch Clements take to robbing banks, trains and coaches, with Pinkerton sworn to bringing them to justice.
Four orphan boys running from the law in New York stumble upon a baby in a carriage. They decide to head west and take the baby which they name Mary Rose with them. Eventually they set up a ranch which they name Rose Hill. Mary Rose grows up to be a beautiful woman and gets involved with a man who kills one of her brothers. Her brothers then explain to her that they found her in New York and she returns to find her real family. During this time Rose Hill is falling apart since her oldest brother has fallen ill and her other two brothers have gone their separate ways.
A dance hall girl is murdered and her body robbed of a quantity of gold obtained illegally. The killer flees into Death Valley and encounters the rightful owner of the gold and her sweetheart.
Jory is a fifteen-year-old boy who joins a horse-drive after his father is killed by a drunkard. The drive's leader and a likable cowhand take the boy under their wing, and find that tragedy has taught him how to take care of himself better than anyone could expect.
After the 1860s Wild West, a group of misfit settlers - including ex-doctor Phil Taylor, prostitute Belle, and homosexual bookseller Julian - decide they cannot live in their current situation in the west. They hire a grizzled alcoholic wagon master by the name of James Harlow to take them on a journey back to their hometowns in the East.
An American actor, impersonating an English butler, is hired by a rich woman from New Mexico to refine her husband and headstrong daughter. The complications increase when the town believes the actor/butler to be an earl and President Roosevelt decides to pay a visit.
A young cavalry officer finds his woman tortured by the Apaches and blames the Army for not properly protecting the outpost, so becomes a deserter and an avenger, stalking and killing Indians without warning.
Priest turned vigilante Father John hunts down a gang of criminals, led by Sam Clayton, who killed a man in a local bar. On the gang's return to the town, they kill the priest, leaving a young parishioner Johnny behind. He now seeks revenge for the death of the holy man.
In the wild west, two brothers embark on a journey to collect a bounty in a desperate attempt to save their home: but what they find along the way is more than they bargained for.
A young outlaw gets involved with a gang of crooks. When he tells them he is breaking away, they threaten to pin a false murder charge on him. But he is rescued and reformed by his sister, and an undercover agent for the express company.
The U.S. Army needs more horses for the Spanish-American War. Hoppy must turn his Bar 20 cowhands into Rough Riders to gather up the horses, and of course bad guys try to sabotage the operation.
After Drew Dixon, an upright young man, is sent west by his religious family to avoid being drafted into the Civil War, he drifts across the land with a loose confederation of young vagrants.
A guitar-playing drifter helps a rancher's granddaughter find her true calling. They soon find themselves in the middle of a land war driven by quirky characters and magical realism.
When Sheriff Jake sees a man at the safe and then finds the payroll gone, he trails him. Just as he is about to arrest him, the man saves his life. Still suspicious, he joins up with the man and later they learn that Melgrove, the towns leading citizen, is trying to take over the area's ranches by having his gang stop all incoming supply wagons. With the ranchers about to sell to Melgrove, the two newcomers say they will bring in provisions.
Dare Rudd takes a shine to his cattleman cousin Tom's girlfriend who asks Tom to hire Dare to head the big cattle drive. Dare loses the money for the drive to cardsharps, but Tom wins it back, but Dare must save Tom's life.
Roy is an oil prospector. His efforts to get drilling rights on an old Spanish land grant are countered by gamblers from an off-shore gambling boat determined to control the land (and oil) themselves.