Private Frank Austin, imprisoned for striking Colonel Kincaid, who was abusing a lame newsboy, escapes to Colorado. Meanwhile, Latin professor Thomas Doyle, his wife Mary and sister Kitty also move to Colorado because of Mrs. Doyle's health and are persuaded by Kincaid to buy a ranch that is worthless because it has no irrigation. While Mrs. Doyle gets well and Doyle's funds run out, Austin, on land bordering Doyle's, strikes gold and is blackmailed by Kincaid to let him have a controlling interest.
Arizona range rider Lon Gilchrist helps stagecoach passengers fight off attacking Apaches. After rescuing a baby and binding her bleeding forehead with his handkerchief, Lon receives a reward that allows him to buy a ranch. Many years later, the rescued child, Lizzie Mayberry, is a waitress in a cheap restaurant, where she meets Lon, who, now wealthy, courts and marries her. Because he is so busy, Lon has his friend Del Beasley look after her. After a misunderstanding, Lizzie has Del take her to the railway station. Thinking that they left together, Lon pursues them.
A Playboy inherits a Western ranch on the condition that he shall run it properly for 6 months. A villain makes an attempt to distract him from reaching the goal, but he, no longer the wastrel of yore, persists and becomes full owner of the property.
Like many Easterners who suffer from consumption, "The White Plague," Jim Warren goes to Arizona for the curative powers of its dry climate. When he arrives in Tucson, though, he cannot find a room because he is a 'lunger.' Ill and despondent, Jim is befriended by Betty Blake, the daughter of rancher and town sheriff Frank Blake, who suggests that he try the open desert. Wandering the desert, Jim happens upon members of the gang headed by Scar-face Jordon, a notorious rustler.
When sponsor Nottingham cancels King Russell's radio program, The Hot Shots try to change his mind. They not only fail but Nottingham's son forces them to take him back to Russell's ranch. Once there he starts playing practical jokes. With everyone disliking him and learning his father is coming, he has a plan to redeem himself.
Dean, the Bailey County Judge, is the boss of both the outlaw gang and the Sheriff. He utilizes the state law that Sheriffs have jurisdiction only in their own county. After a raid the gang merely returns to the safety of Bailey County. The Governor sends Lawyer John Hayes. When he has no success as a Lawyer he leaves town only to return disguised as an outlaw with a scheme that will nab all the culprits.
Outlaws Dale and Tucson quit Wolf's gang. Just as the two are about to rob the stage, Wolf and his gang beat them to it. Dale breaks it up saving the money and this gets him appointed Sheriff. But Wolf shows up and threatening to expose Dale, forces him to let his gang rob the express office.
Marshal Jeff sends for his friend Whit Gordon to help bring law and order to Tombstone. Bull and his gang with the help of the Sheriff and the Judge control the town. After foiling Bull's attempt to stuff the ballot boxes, newly elected Marshal Whit and his pals head to the corral for the showdown with Bull and his men.
Brad Buckner has just bought a ranch. Murdock keeps his rustled cattle on the ranch and sends his men to kill Buckner just as they did the previous owners. But Buckner and his men foil their attempts and decide to search the ranch. To throw Buckner off he kidnaps Buckner's girlfriend and the Sheriff and makes plans to drive the cattle across the border.
Rancher William Norton refuses to sell his cattle for half price, so saloon owner and gang leader Jim Fletcher, contrary to the orders from his secret boss Willard McGowan, the town banker, has his men rob and beat up Norton. Unknown to anyone, Marion, McGowan's adopted daughter is really the daughter of Norton, who disappeared as a young baby when she and her mother were passengers on a stagecoach held up by McGowan. Chuck Saunders, Norton's foreman, goes after the gang for robbing his boss and eventually uncovers the truth regarding Marion's heritage.
The gold mine belonging to "Gun" Barlow is worked out, and Barlow attempts to buy adjacent land, with the hopes his gold vein will continue, from town postmistress Marion Saunders who, keeping a vow she made to her father on his death-bed, refuses.
Sayres and his outlaw gang operate out of a town just across the border and out of the jurisdiction of the Texas Rangers. Ranger Bob Allen is sent across the border where he poses as an outlaw hoping to lure the gang back into Texas. He gets into Sayres' gang displacing the gang boss but the disgruntled ex-boss is able to expose the hoax and Bob is made a prisoner.