Set in the Old West, the stooges are crooked gamblers swindling the residents of a frontier town. They are discovered and must escape into the woods. To elude the sheriff they disguise themselves as Indians. Their plan works until Curly, dressed as a squaw, is forced to marry a local tough guy. The stooges are unmasked and wind up in the hoosegow.
Jose Desmet, a butler, killed his employer because the latter, once a district judge, had long ago condemned Desmet's father, a well known gangster, to death. When Desmet tries to seduce Salazar's daughter, who is heir to a goldmine, kills a woman and the village doctor because they had found out that he was selling weapons to the Indians, a government investigator, Bill Walcome, together with the sheriff, sets out to put an end to Desmet's activities.
American arms dealer Kennedy hopes to make a killing by selling to the "regulares" in the 1916 Mexican revolution. American mercenary Wilson favors the rebel faction headed by Escobar, and they plot to hijack Kennedy's arms; but Wilson also has his eye on Kennedy's wife. Raids, counter-raids, and escapes follow in a veritable hail of bullets.
After a professional gambler kills a Confederate soldier, he finds a map pinpointing the location in the desert where stolen army gold bullion is buried. He plans to retrieve it, but others are searching for it too.
A gunfighter, stranded in the desert, comes across the aftermath of a stage robbery, in which all the passengers were killed. He takes one of the horses to ride to town to report the massacre, but finds himself accused of it. He also finds himself accused of the murder of the local banker, and winds up hiding in the basement of a house where the local sheriff, who is very sick, lives with his daughter.
A group of unlikely travelling companions find themselves on the same stagecoach to Cheyenne. They include a drunken doctor, a bar girl who's been thrown out of town, a professional gambler, a travelling liquor salesman, a banker who has decided to embezzle money, a gun-slinger out for revenge and a young woman going to join her army captain husband. All have secrets but when they are set upon by an Indian war party and then a family of outlaws, they find they must all work together if they are to stay alive.
A band of fierce rustlers is ravaging the region of Las Cruces. Appears an outsider who saves the ranch owner "The Spur" of being kidnapped by members of the band. Thankfully, he was appointed foreman, and his daughter is in love with him. But things are not what they seem and there are murky intrigues in the background.
A doctor from New York travels to a remote plantation in the 1890s to care for a disturbed boy who seems to have inexplicable abilities. She begins treating the child, but in doing so, ignites a war between science and religion as the local priest believes the boy is possessed by the devil and the cause of the village's woes.
Bob Knight, foreman of the Five-Bar Ranch receives a letter one morning from his eastern cousin, Bob Lawlor, saying he will arrive next day for his vacation. Knight loves pretty Sue Jordan, a gay little coquette, and they are engaged. Next morning Lawlor arrives and Knight introduces him to Sue. She immediately is struck with his eastern clothes and manners
In Roy Rogers' Down Dakota Way, the deadly hoof-and-mouth disease has struck the herd owned by evil rancher H. T. McKenzie (Roy Barcroft). To avoid an expensive quarantine on his stock, McKenzie plans to murder the local veterinarian (Emmet Vogan) before the latter can report his findings to the government. Rogers manages to straighten out the situation by appealing to the sensibilities of the aunt (Elizabeth Risdon) of McKenzie's hotheaded hired assassin (Byron Barr). The film also bears several musical numbers from Roy, Dale Evans, and Foy Willing and the Riders of the Purple Sage.
Patricia Medina plays the title character in The Buckskin Lady. Medina is cast as female gambler Angela Medley, who is forced by circumstances to align herself with outlaw Slinger. But Angela has never gotten over her love for honest frontier doctor Bruce Merritt, and at the first opportunity she redeems herself by catching a bullet intended for the doc. Henry Hull delivers the film's most memorable performance as Angela's drunken wretch of a father. Per the title, Buckskin Lady affords the viewer ample opportunity to see Patricia Medina in form-fitting western garb.