The epic tale of the development of the American West from the 1830s through the Civil War to the end of the century, as seen through the eyes of one pioneer family.
Questions arise when Senator Stoddard attends the funeral of a local man named Tom Doniphon in a small Western town. Flashing back, we learn Doniphon saved Stoddard, then a lawyer, when he was roughed up by a crew of outlaws terrorizing the town, led by Liberty Valance. As the territory's safety hung in the balance, Doniphon and Stoddard, two of the only people standing up to him, proved to be very important, but different, foes to Valance.
Harvard graduate James Averill is the sheriff of prosperous Jackson County, Wyo., when a battle erupts between the area's poverty-stricken immigrants and its wealthy cattle farmers. The politically connected ranch owners fight the immigrants with the help of Nathan Champion, a mercenary competing with Averill for the love of local madam Ella Watson. As the struggle escalates, Averill and Champion begin to question their decisions.
Cole Thornton, a gunfighter for hire, joins forces with an old friend, Sheriff J.P. Harrah. Together with a fighter and a gambler, they help a rancher and his family fight a rival rancher that is trying to steal their water.
Following the Civil War, headstrong rancher Thomas Dunson decides to lead a perilous cattle drive from Texas to Missouri. During the exhausting journey, his persistence becomes tyrannical in the eyes of Matthew Garth, his adopted son and protégé.
Will Kane, the sheriff of a small town in New Mexico, learns a notorious outlaw he put in jail has been freed, and will be arriving on the noon train. Knowing the outlaw and his gang are coming to kill him, Kane is determined to stand his ground, so he attempts to gather a posse from among the local townspeople.
When his cattlemen abandon him for the gold fields, rancher Wil Andersen is forced to take on a collection of young boys as his cowboys in order to get his herd to market in time to avoid financial disaster. The boys learn to do a man's job under Andersen's tutelage, however, neither he nor the boys know that a gang of cattle thieves is stalking them.
From Wichita to Dodge City, to the O.K. Corral in Tombstone, Wyatt Earp is taught that nothing matters more than family and the law. Joined by his brothers and Doc Holliday, Earp wages war on the dreaded Clanton and McLaury gangs.
After avenging his family's brutal murder, Wales is pursued by a pack of soldiers. He prefers to travel alone, but ragtag outcasts are drawn to him - and Wales can't bring himself to leave them unprotected.
Half-breed Keoma returns to his border hometown after service in the Civil War and finds it under the control of Caldwell, an ex-Confederate raider, and his vicious gang of thugs. To make matters worse, Keoma's three half-brothers have joined forces with Caldwell, and make it painfully clear that his return is an unwelcome one. Determined to break Caldwell and his brothers' grip on the town, Keoma partners with his father's former ranch hand to exact violent revenge.
With his bronco-busting career on its last legs, Junior Bonner heads to his hometown to try his luck in the annual rodeo. But his fond childhood memories are shattered when he finds his family torn apart by his greedy brother and hard-drinking father.
In 1897, veteran bounty hunter Max Borlund is deep into Mexico where he encounters professional gambler and outlaw Joe Cribbens — a sworn enemy he sent to prison years before. Max is on a mission to find and return Rachel Kidd, the wife of a wealthy businessman, who as the story is told to Max, has been abducted by Buffalo Soldier Elijah Jones. Max is ultimately faced with a showdown to save honor.