Perrin and his partner get paid a big sum of money at the end of their cattle drive. Shortly thereafter, the partner is found with a knife in his back and Perrin is blamed for the murder.
When Tex is brought in to fight in a range war between the cowmen and the nesters, he meets his old outlaw boss Lassiter. He learns Lassiter is behind the feud when Lassiter asks him to join up with his gang. Tex refuses and instead sets out to stop the feud but no one will believe him that Lassiter is responsible.
Tex and his sidekicks arrive to help out his friend Jeffers, a railroad owner, only to find that he has been killed. They quickly run into trouble with an outlaw gang in their attempt to find the mysterious ghost train that supposedly runs on Jeffer's line.
Knowing that is contains valuable helium gas, a gang of bad guys first tries to purchase the ranch which Gene straw-bosses. When that fails, they lay a hidden pipeline to snag the gas.
David Ross organizes the ranchers into a vigilante group to rid the town of outlaws. The plan succeeds but the trouble starts when some of the men form a new vigilante group and posing as the original one plunder for loot.
Stony's brother George has been accused of murder and the Mesquiteers have returned to prove his innocence. But they find that Harvey rules the town along with his stooge Sheriff Gray and that George won't get a fair trial.
Henry Jethrow is after the Wilson ranch. He has George Wilson unknowningly sign a note for the ranch, has him killed, and then presents the note. The Pinto Kid, investigating cattle rustlers, accidentally drops his glove at the murder scene and now has a price on his head. He has Beth Wilson turn him and use the reward money to reclaim the note. Now he has to escape jail and find the real killers.
Ranger Bill Williams goes to prison to get information on Chuck Adams. Then a fake posse chase gets him invited into Adams' gang. But just as he learns who Adams' boss is and is about to make his move, his cell mate who escaped from prison returns to identify him.
The Hawk has broken out of prison and the Sheriff and Sorrenson have a plan to have Whitlock pose as the Hawk, infiltrate the gang, and recover the stolen bonds. All goes well until The Chief who knows the real Hawk arrives.
The Sheriff and his deputies are after Scar Adams. Scar is the brother of Alice Denton, the girl Deputy Tom plans to marry, and when the Sheriff is wounded she makes Tom refuse the job of Sheriff. But when Scar kills his father, Tom puts on the badge and takes out after him.
A young man is lured into a cardgame by a crooked dealer. He is about to lose all the money that was given to him to get medicine for his mother when a local cowboy comes to his rescue.
Just after Pocatello's brother is killed, a wounded Pocatello arrives being chased by the Sheriff. Larkin switches the identity of the two brothers and then expects Pocatello to assume his brother's role in the outlaw gang.
A cowboy tries to protect a young woman whose father was murdered because he had railroad maps that showed the location of a proposed new line. Now the killers are after her because they think she has the maps.
Doran and the Sheriff have a scheme to bring in an outlaw gang. Doran is sent to prison so he and the gang leader Mitchell can break out. This gets him into the gang but he is in trouble when it's revealed he is working with the Sheriff.
A cowboy hears rumors that an old friend who once headed a criminal gang and had since gone straight is now back on the wrong side of the law. He goes to investigate.
When Steve Harper chases down some rustlers, he loses his gun in the ensuing fistfight. After Wilson is killed, Steve's gun is found nearby and he as arrested. Jimmy Wilson breaks him out of jail and he heads after the real killer.
The Topeka Terror is a western film of 1945 directed by Howard Bretherton. The land-rush opening of the Cherokee Strip brings in its wake a scattering of outlaws and claim jumpers. Among these is a crooked promoter. Trent Parker (Frank Jacquet), and his henchmen who plan a huge swindle by compiling falsified reports, putting the claims of honest settlers into the names of various henchmen. Clay Stevens (Allan Lane), a government agent posing as a drifting cowhand, advises the settlers to organize their resistance. Ben Jode (Roy Barcroft), the gang leader, runs for sheriff so he can gain full control of the town.