In this western, a rancher's son rides out for revenge against the rustlers who killed his father. The pursuit stretches between Montana to Arizona and it becomes more difficult because though the son knows the killer's name, he has never seen his face. Fortunately, the killer doesn't know what the son looks like either.
Two women and two kids are stranded in the Old West when bad guys (posing as Indians) try to snag the stagecoach's cargo. Pitted against nature, time, and the pursuing baddies, this unlikely team must trek over the mountains to reach safety.
Fanning has his men rustle horses and then blame it on a wild horse named Wildfire. Happy and Alkali arrive and immediately get into trouble with Fanning and his men. When Alkali is shot, Happy catches the outlaws but the Judge not only releases them, he discharges the Sheriff and tries to arrest Happy for rustling. Happy escapes and he and the Sheriff then set out to prove who the real rustlers are.
When attacked by two dogs, Joe Gilmore leaves them on the desert to die. Later one of the dogs saves John Blake from drowning. Men arrive claiming the dog is killing their chickens. They want to kill the dog but John convinces them the dog's fate should be determined by a trial.
Native son returns from school in Spain to California in 1855 and finds corrupt politicians stealing land from old California families. He becomes a sort of Robin Hood in order to fight them.
Hanley shoots a man and then frames Bill Roberts. Being the Judge he then holds court planning to hang Bill but Bill's friends effect his escape. Andy tries to lead Hanley astray by misleading him as to Bill's location. But Bill changes plans and Hanley catches up with him and this leads to the showdown.
A ranch owner fires his ranch hands and brings in women to replace them. The owner's daughter wants the male hands back and comes up with a plan to do it.
When Sundown wins a horse race he is paid with a deed to a ranch. Arriving at the ranch he finds the Prestons already living there. They bought it from the fake land agent Taggart who then frames Sundown for murder.
Jack rides into trouble when he meets up with Bill Meeker and his outlaw gang. Rescued from the gang's clutches by Don carlos, he joins forces with Carlos and with the help of Lolita who learns of the gang's next raid, they go after the culprits.
After deceitful Indian agent Grat Bandas has his men shoot Brother Van, gunfighter Linc Prescott saves the peaceful circuit rider and agrees to help him put a stop to Bandas's plans to start an Indian war and grab their land for himself. Meanwhile, Prescott takes a shine to the daughter of a local rancher.
Canadian Mountie Mason is sent south of the border to look for a horse thief with only a watch chain for evidence. He befriends young Andy and when Calhoun hits Andy, Mason and Calhoun fight. In the scuffle Calhoun's watch with the missing chain is dislodged. Mason then sets out to bring in Calhoun and his gang.
Reporter Speed Morgan helps Flash Barrett escape from the police and this gets him into Flash's gang where he poses as a gangster. Flash and his gang head west guning for Bill Miller who failed to send some diamonds on to Flash. Speed hopes to bring Flash to justice but is in trouble when his true identity is revealed.
Montana ranch owner Cyrus Bigbee sends his foreman, Gene Autry, and Rawhide Buttram to his Canadian timber land to stop the marriage of his daughter Sandy to Todd Markey, whom he dislikes. Sandy wants to turn the property into a dude ranch, with Carolina Cotton and the Cass County Boys (Fred S. Martin, Jerry Scoggins and Bert Dodson) among the entertainers, and runs up against local timbermen who want it for cutting timber. When a Mountie is murdered, with suspicion pointing to Todd, Gene finds the real culprit and brings peace to the area.
Like 1940's Melody Ranch, the 1941 Gene Autry vehicle Down Mexico Way was designed as a "special", to be promoted separately from Autry's regular B-western series as an A-picture attraction. The story gets under way when a pair of con artists, Gibson (Sidney Blackmer) and Allen (Joe Sawyer), breeze into the town of Sage City claiming to be movie producers. The two scoundrels promise to film a movie in the little burg on the condition that the townsfolk pony up the necessary production fees.