A half Mexican, half Irish gunman called The Irish Gringo and his pals come across a little girl wandering in the desert. It turns out her grandfather was murdered by a gang looking for the Lost Dutchman mine, a map of which is drawn on the shirt she is wearing, and now the outlaws are after her.
Lawyer Rontel has made Geologist Sheffield his prisoner and by power of attorney is using his money to buy the ranches of those driven off by his hired men. But when he goes after Hayden, Tucson and Stoney arrive and things begin to change.
When his young son is shot, John Wellington kills the culprit and flees. But his son Johnny recovers and is raised by Sir George. Some twenty years later Johnny sets out to find Sir George's missing granddaughter.
Traveling with Doc Parker's medicine show, Gene finds his old friend Harry Brooks wounded and the Sheriff after him for murdering his father. Gene also sees that Craven and his gang are looking for Brooks. Finding clues that Craven was behind the murder, Gene has a plan utilizing the medicine show wagon that will trap the gang.
Jack Thornton has trouble winning enough at cards for the stake he needs to get to the Alaska gold fields. His luck changes when he pays $250 for Buck, a sled dog that is part wolf to keep him from being shot by an arrogant Englishman also headed for the Yukon. En route to the Yukon with Shorty Houlihan -- who spent time in jail for opening someone else's letter with a map of where gold is to be found -- Jack rescues a woman whose husband was the addressee of that letter. Buck helps Jack win a $1,000 bet to get the supplies he needs. And when Jack and Claire Blake pet Buck one night, fingers touch.
When Sundown wins a horse race he is paid with a deed to a ranch. Arriving at the ranch he finds the Prestons already living there. They bought it from the fake land agent Taggart who then frames Sundown for murder.
When John Mason's father is killed, John is wounded. Attracted to his nurse Alice, a conflict arises between him and his friend Ben who plans to marry Alice. John later finds the killer of his father but goes to face him not knowing Ben has removed the bullets from his gun.
A man posing as Mark Henry is after Henry's oil land but Henry's niece is part owner and he needs to marry her off to his henchman Slager. Mountie Jim Sullivan arives posing as a wanted man and is soon caught up in the plot when Slager, wanting everything for himself, kills his boss and makes Jim a prisoner.
Grant hides stolen money in the luggage of Bonnie Shea who is moving west. Later when he and his men arrive to retrieve the money, they also kidnap Bonnie. This sends Reasonin' Bates and his cowhands on their horses after the gangsters in their cars.
A mining engineer teams up with a crusty deputy sheriff to solve the mystery killings at an old mine where the owner's family waits for him to die, and where a valuable radium strike may have been made.
A landslide has diverted water from the Baldwin ranch to Cambert's. With their cattle dying, Cambert refuses to let them have any water. Easterner Larry Knight takes a job with the Baldwins and he has a plan to divert the water back to the Baldwin ranch. But Phil, jealous of Kitty's attraction to Larry, lets Cambert know of the scheme.
Jack rides into trouble when he meets up with Bill Meeker and his outlaw gang. Rescued from the gang's clutches by Don carlos, he joins forces with Carlos and with the help of Lolita who learns of the gang's next raid, they go after the culprits.
Chris Morrell, the guardian of half-Indian girl Nina, is helping her find her missing white father. so she can cash in on her late mother's oil lease. Outlaw Sam Black is after the girl and her father as well. Besides dealing with the Black gang, Morrell has to find another robber, Jim Moore, who switches clothes with him after he finds Chris unconscious from a fight with Sam Black. Along the way, he meets a lady who's the sister of Jim Moore, another bad hombre who's in cahoots with Jim Moore, and an old friend who takes in Nina and helps Chris locate Nina's father and fight off the various desperadoes
Tobin is after the bandit Zanti who killed his parents. He finds him just as Zanti is about to kill Dusty and kidnap Ruby. Saving the two, he goes after Zanti. He catches him but Zanti escapes the Sheriff's handcuff's and this time Tobin has to chase him into the desert.
Gangster Chandler and his accomplice Tracy arrive at a dude ranch. Cowboy Kentucky arrives at the same time. When Tracy double-crosses his boss and has the stage robbed, Kentucky finds the outlaws and brings them in. Tracy frames him for the murder of the driver but his pal Cactus gets him out of jail. He returns just as Chandler shoots Tracy and Kentucky finds himself arrested for another murder.
Henry Jethrow is after the Wilson ranch. He has George Wilson unknowningly sign a note for the ranch, has him killed, and then presents the note. The Pinto Kid, investigating cattle rustlers, accidentally drops his glove at the murder scene and now has a price on his head. He has Beth Wilson turn him and use the reward money to reclaim the note. Now he has to escape jail and find the real killers.