Greek Conniston, after living a life of ease and comfort, is forced by his millionaire father to get a job and earn his own living. While traveling West with his friend Roger Hapgood, Greek meets Argyl Crawford and, entranced by the girl, takes a job on her father's ranch.
During a violent disagreement, a miner strangles his partner and accidentally shoots the man's wife. He then deserts his own wife and son to elope with the saloon keeper's daughter. As they are fleeing, the girl discovers the deed and insists upon caring for the baby found in the dead wife's arms.
Cattleman Flint cuts off farmer Sims' water supply. When Sims' son Ted goes for water, one of Flint's men kills him. Cheyenne is sent to finish off Sims, but finding the family at the newly dug grave, he changes sides.
While out on a plundering expedition, outlaw Dick Durand comes upon a band of Indians attacking a group of settlers. Dick opens fire on the Indians, but before he forces them to flee, they kill everyone except three children and Durand himself.
The setting is the Old West town of Paradise, Nevada, where a young woman, Mercedes Murphy (played by Louise Glaum), co-owns and operates a combination saloon and dance hall called the Red Hen with her business partner, Slick Barney (played by Jack Richardson). Her little half-sister, Olive "Live" Sumner (played by Mildred Harris), who is crippled, lives with her and she makes every effort to protect the child. A tough, but good-hearted businesswoman, Mercedes shows a tender side at home with Live. Her partner, Slick, and a cowboy called the Heller (played by John Gilbert), who has a heart of gold, are both interested in Live.
Harry is thrown out of town and on his way across the desert meets a minister and his family; when the man is killed in an Indian raid, Harry takes care of his little daughter, later puts on the minister's frock and reforms a town.
Orphan Hilda Swanson's prayers are answered when a Swedish-American colonization company agrees to send her to America. Aboard the steamer, she meets Olaf, a young Swede, and Donna, an enemy courier who is posing as a passenger. Learning that the secret service is on her trail, Donna sews secret documents into the hem of Hilda's skirt. She then sends a wire to her comrade Felix Martinez, notifying him to intercept the Swedish girl.
The story takes place in a small struggling mining town located in the foothills of the California mountains at the time of the gold rush. The camp is suffering from a long string of bad luck. With only one woman in their midst, it seems as though the miners have no future. However, the tide turns when a small boy is born. "Thomas Luck" is the first newborn the camp has seen in ages; things are looking up.
John Gregg and his daughter Mary, on their way to Burro Springs, a boom mining town, lose their way and stumble into "Jawbone," a dilapidated town. Here they meet Mike Hernandez, a good-looking bad man. Mary, thinking Mike a gentleman, takes a liking to him. "Cheyenne" Harry, a homely looking good man, comes to Jawbone and Mary believes him to be a weak character. He becomes fascinated with her. Gregg hires Mike Hernandez to guide him to Burro Springs, displaying his small store of gold when paying Hernandez. Later, Gregg and his party become lost in the desert, and run out of water.
Sylvia Mason, a mysterious girl, lives in a cabin by herself and sells her bead work to the visitors at a large hotel nearby. At the hotel, Sylvia meets Easterner Henry Hilliard, who falls in love with her, but she refuses to marry him and will not explain her reasons. Thus Henry returns East without learning that Sylvia's father had been murdered by his private secretary Jack Leslie in revenge for her refusal to marry him. One night after Henry's departure, Leslie, now known as the outlaw "The Shadow", breaks into Sylvia's cabin. There is a struggle that leaves Sylvia unconscious, and when she awakens she finds a note claiming that because Leslie has violated her, she must marry him.
Madge Black witnesses her best friend Nan Westland, kissing her husband, successful lawyer Jeffrey Arnold Black, a successful lawyer, and orders Nan from the house. Angered by her refusal to let him explain, Jeffrey leaves his wife and son David, Jeffrey meets Nan on a westbound train. Though he does not love her he offers his protection and the next year they welcome a son, William. Nan pleads with him to divorce Madge and marry her for the sake of their son, but he will refuse. Distraught, she marries Ben Richardson, a client of Jeffrey's client, leaving their son behind. Twenty years pass with David becoming a responsible adult while half-brother William now known as “Rodeo” becomes the leader of a lawless band of robbers. Meanwhile Ben Richardson and Nan have become owners of Chanceland, a gambling-house in Colorado and it is there that things reach a climax between the near identical brothers.
After her mother's death, Mary not only becomes the household slave of her overbearing father, Scottish American Andy MacTavish but also becomes a mother to her little sister Ruth at their home on the Dakota plains.
After being unfaithful to "The Stranger", who committed a murder on her account, Cherry Millard, known as "The Siren", leaves to work in a dance hall in the Western town of Nugget. When Burt Hall arrives in town to deliver a will to the heirs of Bruce McClade, he is captivated by Cherry, who learns of Burt's mission. Discovering that the will dictates that Dr. Langdon, a friend of the family, is to receive $25,000, Cherry decides to impersonate Langdon's daughter Rose and thus gain possession of the money. In the meantime, The Stranger, who has been freed from jail, returns, recognizes Cherry as The Siren and kills her. This frees Burt from her evil spell, and The Stranger, now insane, follows The Siren's spirit into the desert.