Harris and Rigby own a circus. Rigby is a counterfeiter and frames his partner. The Mesquiteers learn Rigby is the culprit and get a confession from one of his men only to lose the case when the man is murdered in jail. The Mesquiteers try again and send Lullaby to try and win some of the fake bills in a card game.
When Missouri farm boy Jesse James witnesses the lynching of his father by the Yankees, he forsakes his family's homestead to find his brother Frank, a soldier in Quantrill's Raiders, a renegade band of Confederates. Bent on revenge, Jesse begs to join the raiders.
Tom Keene, formerly George Duryea and latterly Richard Powers, made his final starring appearance in the Monogram western The Painted Trail. Keene is cast as a former federal agent who is drawn out of retirement to stem the activities of smugglers Boss (Leroy Mason) and Driscoll (Walter Long). Disguising himself as an outlaw, our hero gains the confidence of the two desperadoes, only to be found out at the least appropriate time. Rest assured that Keene saves the day and manages to march ingenue Ann (Eleanore Stewart) to the altar.
Afflicted with a terminal illness John Bernard Books, the last of the legendary gunfighters, quietly returns to Carson City for medical attention from his old friend Dr. Hostetler. Aware that his days are numbered, the troubled man seeks solace and peace in a boarding house run by a widow and her son. However, it is not Books' fate to die in peace, as he becomes embroiled in one last valiant battle.
A wagon train heads west from Independence, Mo., along the Oregon Trail, led by proud cowboy Clint Belmet. On board are feisty young widow Nancy Wellington and her toddler, Sonny, as well as the older Abby Masters, who begins a romance with scout Jim Burch. Along the way, the wagon train battles Indians led by Kenneth Murdock, a trapper who doesn't welcome competition for Oregon's lucrative fur trade. Wagon Wheels is a 1934 remake of 1931's Fighting Caravans, using stock footage from the original.
The Carson City Kid and partner Laramie are outlaws. When his partner is caught the Kid, his identity being unknown, takes a job in Jessup's saloon. Here he see Jessup cheat Waren out of his money. Warren then robs Jessup posing as the Kid but gets caught. To gain his freedom, Laramie identifies Warren as the Kid. Realizing Jessup is the man that killed his brother, the Kid must find a way to clear Warren and get Jessup.
A prospector is looking for a lost gold mine and finds aid in his search through the efforts of his friend, Stormcloud, whom he has aided in the past. Stormcloud gives the prospector's son a map leading to the mine in repayment for his past kindness. When a claim jumper learns about the map, he targets the prospector and his son in order to get the treasure.
Manzanita Springs ia a combination small airline and spa and Vance Brados wants it. He pays their mechanic to have the planes run out of fuel so his men can rob the gold shipments and kill the pilots. After Sheriff Roy Rogers catches the mechanic, Roy plans one more gold shipment to get proof and this time his men will be ready. But it looks like Roy's plan will fail when Brados suspects a trap and call off the raid.
When his young son is shot, John Wellington kills the culprit and flees. But his son Johnny recovers and is raised by Sir George. Some twenty years later Johnny sets out to find Sir George's missing granddaughter.
A cowboy escapes from jail with the help of his girlfriend, and goes after the men he believes are responsible for his brother being shot down by lawmen.
Brade has hired Rattler Haynes to kill Tom Shaw. But when Shaw intercepts a message between the two, he alters it hoping it will cause the two outlaws to fight each other.
Doran and the Sheriff have a scheme to bring in an outlaw gang. Doran is sent to prison so he and the gang leader Mitchell can break out. This gets him into the gang but he is in trouble when it's revealed he is working with the Sheriff.
A wounded archaeologist crawls into the camp of three kindhearted cowboys. When the cowboys bring him to a nearby trading post, he's murdered after he lets slip a secret about a hidden cave. Investigating his death, Ken and his friends encounter a land dispute between a pair of neighboring ranches, an arrogant German baron and a mysterious shack that houses a great secret.
In the lawless West, The Cowboys, a notorious brotherhood of killers and thieves, reigned over the land with brutal fists and fast guns. Fate had finally caught up with them and now the merciless gang has but a single surviving member. When a deputized gunslinger takes up the call to hunt down the last Cowboy, the chase is on and the bullets fly, and only one of these hardened men can survive.
When the showboat hits town, two men use the parade as a distraction to rob the bank. Their accomplice is Pop, the clown from the showboat. He leaves the money on the boat and tells his daughter Patsy to bring it to him at a later stop on the river. Gene's investigation of a bank robbery takes him to the showboat where he becomes a performer. Gene and Frog try to find the money while helping Patsy and her father.