An evil ranch foreman tries to provoke a range war by playing two cattlemen against each other while helping a gang to rustle the cattle. Each cattleman blames the other for missing cattle. With the help of Bill Cassidy (Hop-along, because of an earlier bullet wound) and Johnny Nelson, the warring cattlemen join forces to do in the outlaws.
Hoppy's friend Dennis owns a rich gold mine. Frazier who owns the adjoining mine and wants the Dennis mine, has Dennis killed. Hoppy steps in to take over running the Dennis mine and learns Frazier's men sneak into and work the Dennis mine at night. Hoppy captures one of Frazier's men only to be captured in return by Frazier and left to die in a burning building.
Posing as a cattle buyer, Hoppy crosses over into Oklahoma where the Jordan brother's and their outlaw gang operate outside the law. After receiving an unfriendly reception when he finds them, he, California, and Johnny rustle their cattle and drive across the river into Texas. He hopes they will cross over to retrieve their cattle and then he can arrest them.
When Ranger Hoppy's falsely accused young ranger friend is killed while supposedly trying to escape from jail, Hoppy is blamed and drummed out of the Texas Rangers.
As rustled cattle have mysteriously disappeared, Johnny sends for his friend Hoppy, Hoppy arrives and immediately suspects Dan Slack. Realizing his telegram about Slack was intercepted, he locks up the operator Lafe knowing he can escape. Tailing Lafe he finds a secret entrance to a mine and inside finds the missing cattle. But Slack's men also find him just as the cattle are stampeded through the mine shaft.
Roy Rogers is a cowboy who joins the Border Patrol, only to have his buddy Tommy get killed at a local saloon. Determined to get revenge at any cost, Roy and Rusty cross the border in search of Arizona Jack, the man responsible for Tommy's death.
Father Kino , a 17th-century Jesuit missionary, dedicated his life to helping Native Americans in the Southwest by teaching them agricultural skills as well as building missions and spreading Christianity. An explorer, astronomer and map maker, Father Kino surmounted numerous challenges as he journeyed through California, Arizona and Mexico.
When attacked by two dogs, Joe Gilmore leaves them on the desert to die. Later one of the dogs saves John Blake from drowning. Men arrive claiming the dog is killing their chickens. They want to kill the dog but John convinces them the dog's fate should be determined by a trial.
Belle Langtry runs a town being taken over by cattle rustlers. She is also a front for the outlaws, who are led by Steve Fraser. Hoppy gets elected sheriff and cleans up the town with help from the Bar 20 boys.
The Rough Riders are after a gang of rustlers. Marshal Roberts is posing as a wanted outlaw, McCall is the Marshal supposedly after him, and Sandy is on hand as a cook. Roberts hopes his joining the gang will help bring them in.
Burton is after Clark's ranch. He gets the banker to refuse to renew Clark's note and then sends his men to rustle his cattle. Hoppy is Clark's new foreman and is on to Burton's scheme. But just as he learns of the rustling and is about to go after the gang, the Sheriff arrives and arrests him for hiding Johnny who has been accused of robbery.
Dyer is buying ranches and then retrieving his check by having his gang kill the owner. Bob Worth arrives just as Buck Morton is killed and gets blamed for the murder. Fleeing from the Sheriff, Bob teams up with the Mexican outlaw Golinda. Having seen Dyer pay off his men, he has a plan to trap him and Golinda is just the man he needs to make it work.
Brade has hired Rattler Haynes to kill Tom Shaw. But when Shaw intercepts a message between the two, he alters it hoping it will cause the two outlaws to fight each other.
Tex is up against a group of hooded outlaws. When he shoots one, he uses the hood to infiltrate the gang. Almost caught by them, he escapes only to be arrested by the Sheriff who thinks he's one of the gang.