In pre-Revolutionary America, the efforts of a Colonial officer trying to broker a peace deal between Indian chief Pontiac and British and American settlers are threatened by the commander of a Hessian mercenary unit who embarks on a campaign of extermination against the Indians.
Jerry Johnson inherits a 50,000 acre ranch. Lucky Miller wants to take over the ranch. Roy is trying to get a railroad spur right of way. Lucky has a woman come west to marry Jerry to get control of the ranch. After the wedding, Lucky has the owner killed. Roy’s gun is substituted for the murder weapon, so Roy is put in jail.
Lightning Carson's nephew has been falsely accused of murder. To get in with the gang, Lightning poses as a Mexican. He also appears as himself making his costume changes at his sister's ranch. Just as he about to bring in the gang, a henchman finds evidence of his masquerade and arrives to expose the hoax.
Mountie Matt O'Brien is assigned to escort Miss Owens to a remote outpost. But when he finds an illegal mining operation there that is smuggling gold across the border, his superior Sgt. Means orders him to leave.
In the midst of the Civil War, Lassiter has a plan to get control of California. Working out of St. Joseph, he plans to send forged messages to the troops on the west coast via Pony Express. First he attempts to bribe Pony Express ride Roy Rogers. When Roy refuses he turns to the outlaw Johnson and his gang and this leads to trouble.
Roy returns home to fine a range feud between the cattlemen and the sheepmen. When his friend is killed he finds the rifle had a defective pin. He learns the rifle belongs to a ranch hand named Barker and that a third party has caused the feud. When he captures outlaws trying to blow up a dam, he claims Barker was the killer. But Barker has switched rifles and the outlaws now accuse Roy and Roy finds himself in trouble.
Finding Indians stealing from his ranch, Gene learns they are suffering from malnutrition. Store owner Martin is cheating them and now he is after the Chief's valuable necklace. When the dying chief is found, having been attacked and robbed, Martin blames Lakhona who would become the new chief. When Gene helps Lakhona they soon find themselves fleeing from the law.
Eduardo Belmonte overhears his new step-mother, Maria, and her lover, Don Ricardo Gonzales plotting to take over the Belmonte rancho on the night of the fiesta given by her husband, Don Carlos Belmonte. Eduardo offers Maria money if she will depart the hacienda premises, but she refuses and then accuses Eduardo of making love to her. The old Don doesn't take kindly to his son hitting on his step-mother and attacks him in a rage. The lights go out, the father is killed and Maria blames Eduardo, who escapes from the house, chased by Ricardo's men. The Cisco Kid and Pancho rescue Eduardo, who has been shot, and hide him while they investigate. Cisco discovers that bullets from Maria's gun, a handy little derringer, are the same type that killed Don Carlos. But the Alcalde arrests Cisco and Pancho, and Cisco is "supposedly" executed by a firing squad, but IS NOT shot and escapes by a trick. And now Maria and Ricardo are in real trouble with Cisco on the loose.
In Old California, a young Frenchman transporting a chest full of silver travels by stagecoach to San Marino, to complete a complex business deal. The stagecoach is ambushed by a band of men whose leader, a mysterious bandido known as Cisco (Gilbert Roland), claims the silver is money that was extorted over a period of years from the poor people of California. The bandits take the money and escape, but Cisco stays behind with the Frenchman -- who, it turns out, is actually a lovely mademoiselle, Jeanne DuBois (Ramsay Ames). She follows him to the bandit's lair, where Cisco tells her he intends to return the stolen money to the poor people. The two rivals are irresistibly drawn to each other, however, and as a token of love Cisco offers to return the money to Jeanne instead. Now she must decide whether to complete her business deal, or to comply with Cisco's wishes and redistribute the wealth.
Rancher Reynolds has fired his men and hired killers and is now using a crooked land deal to put the other ranchers off their land. Calico finds the reason why when he runs into his old nemesis Porter.
Cattlemen's Protective Association agent Tom Wade and his partner Happy are assigned to look into the disappearance of rancher John Carroll, who has been abducted by Carson, who wants to use his out-of-the-way ranch as a base for his smuggling operations. Complications arise as Carrol's daughter, Rita, looking for him, has an unfriendly run-in with Wade, then later is herself kidnapped by Carson.
Jim Waters arrives at Ed Parks' ranch to find Parks' cattle herd mysteriously increased. Hamp Harvey has been losing cattle and he suspects Parks. But the culprit is Harvey's foreman Brent who gets his orders from the town's leading citizen Sig Barstell. Barstell wants Harvey's ranch and after trying to frame Harvey by killing Parks, Waters takes over and goes after both the killer and the rustlers.
Parolee John Carver seeks the stolen money he has hidden, but so does his girlfriend, lawyer and cellmate. Tom and Chito are hired to get him across the border into Mexico and find themselves caught in the middle.
When the showboat hits town, two men use the parade as a distraction to rob the bank. Their accomplice is Pop, the clown from the showboat. He leaves the money on the boat and tells his daughter Patsy to bring it to him at a later stop on the river. Gene's investigation of a bank robbery takes him to the showboat where he becomes a performer. Gene and Frog try to find the money while helping Patsy and her father.
Tex Weaver is working under cover to bring in a gang of bank robbers. When he is killed, Tim Ross, a marksman with Doc Shaw's traveling show, takes over. Posing as a Mexican he lays a trap for the gang.
Poachers are harassing toll road owner Jen Larrabee. They want her land because it holds valuable minerals. Autry and the Cass County Boys, mistaken for Texas Rangers, help out.