Ann Fenwick is a witness to a bank robbery in the U.S. and the bandits, led by Trigger and Leon capture her and when she disappears, a warrant is issued for her arrest as a material witness. The bank robbers flee across the border into Canada where they steal a trailer in which they lock Ann and the loot. The hitch breaks and the trailer plunges into a lake. Sergeant Renfrew and Constable Kelly, of the Canadian Mounties, rescue Ann and she tells them she is a hitch-hiking tourist and gives a false name. Renfrew sends Kelly for aid, Ann escapes and Kelly returns with the news that she is wanted. The leader of the gang, Cardigan, sends the gang back for Ann and the loot, which Ann has hidden in a trappers cabin, just before Trigger recaptures her. Renfrew goes to her rescue, but is also captured. But reliable Constable Kelly is somewhere in the woods.
In the lawless West, The Cowboys, a notorious brotherhood of killers and thieves, reigned over the land with brutal fists and fast guns. Fate had finally caught up with them and now the merciless gang has but a single surviving member. When a deputized gunslinger takes up the call to hunt down the last Cowboy, the chase is on and the bullets fly, and only one of these hardened men can survive.
In order to find out who is smuggling guns to the Indians, an army officer pretends to have been demoted and hold a grudge against the army, hoping that the smugglers will try to contact him and take him into their gang.
Gene Autry is assigned to safely transport supplies to a band of settlers. The villains, headed by Ross McLain, intend to bushwhack Autry, grab the supplies, and sell them at high prices to a local mining camp.
Tom Keene, formerly George Duryea and latterly Richard Powers, made his final starring appearance in the Monogram western The Painted Trail. Keene is cast as a former federal agent who is drawn out of retirement to stem the activities of smugglers Boss (Leroy Mason) and Driscoll (Walter Long). Disguising himself as an outlaw, our hero gains the confidence of the two desperadoes, only to be found out at the least appropriate time. Rest assured that Keene saves the day and manages to march ingenue Ann (Eleanore Stewart) to the altar.
When an outlaw is captured and scheduled to hang, the wife of the local deputy makes a decision that will forever change her life. Mabel is in love with the arrested man. Will she remain loyal to her husband Jonathan or follow her heart?
The Sheriff and his deputies are after Scar Adams. Scar is the brother of Alice Denton, the girl Deputy Tom plans to marry, and when the Sheriff is wounded she makes Tom refuse the job of Sheriff. But when Scar kills his father, Tom puts on the badge and takes out after him.
Jim Latimore's ranch is a thorn in the side of the ruthless Gonzales brothers and his marriage to their cousin Rosaria rankles even more. Bandit chief El Matanza is hired to rid them of Latimore and his baby son is taken to be raised as a Gonzales. Three years later five of Latimore's friends arrive to reclaim the boy, replace Rosaria in her home and avenge their murdered compadre.
Roy returns home to fine a range feud between the cattlemen and the sheepmen. When his friend is killed he finds the rifle had a defective pin. He learns the rifle belongs to a ranch hand named Barker and that a third party has caused the feud. When he captures outlaws trying to blow up a dam, he claims Barker was the killer. But Barker has switched rifles and the outlaws now accuse Roy and Roy finds himself in trouble.
The son of Django searches for the murderer of his father and is thereby involved in a war between two factions headed by former acquaintances of his famous parent.
Ted Warren returns from WWI to find that everyone thinks he was dead. The culprit is Kent who intercepted his mail, rustled the Warren cattle, took over the Warren ranch, and is now after Ted's girl friend. When Kent's henchmen fail to kill Ted, Kent shoots Ted's father and leaves him for dead. But only wounded, the plan is to have Warren appear as a ghost to get a confession from Kent.
In Old Wyoming, a gang is plundering stagecoaches of shipped currency and a crusading newspaper editor is trying to get the local marshal replaced, because of his apparent failure to catch the gang, which seems to disappear into thin air after every robbery. The situation escalates when one of the stage drivers is mortally wounded; so the marshal sends for his friends, the Range Busters, to help him catch the criminals. Meanwhile, even the marshal's fiancee, the editor's daughter, turns against him in favor of an aggressive agitator for law and order - who secretly is leading the robber gang.
For revenge the outlaw Morgan steals the Carruthers young son. Seventeen years later Carruthers arrives in the valley where Morgan, his gang, and the now grown Bob hide. After Morgan shoots Tracy, he tells Bob that Carruthers did it and sends Bob out after him. But unknown to Bob, Morgan has put blanks in his gun.
Black Jack Murphy is the brains in an outfit of outlaws who rob the bank at Tusca City. All goes to plan with the heist but once the loot is safely obtained Jack's men lose no time in trying to double cross him. Wily Jack manages to outfox them at first and gets away with the cash but they soon catch up with him again and not only make off with the money but leave him crippled and carrying multiple causes for wanting revenge. This need for amends possesses Jack with an all consuming passion and he sets out to get even with each of his unfaithful former compadres but has his particular sights set on Indian Joe and Sanchez who abused and killed his beloved sister.
After a stagecoach is robbed and the passengers murdered, a long and tangled series of surprise attacks and murderous double-crosses, leaves the coach's strongbox in the hands of the killer Lasky. It is up to the legendary hero Sartana to track down the missing money and determine just who is ultimately behind the grisly robberies and killings.